Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression

Fusing the TATA box-binding protein (TBP) to other DNA-binding domains may provide a powerful way of targeting TBP to particular promoters. To explore this possibility, a structure-based design strategy was used to construct a fusion protein, TBP/ZF, in which the three zinc fingers of Zif268 were li...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Kim, Jin-Soo, Kim, Jaesang, Cepek, Karyn L., Sharp, Phillip A., Pabo, Carl O.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1997
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20489/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108026/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.3616
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