Murine Ccl2/Cx3cr1 Deficiency Results in Retinal Lesions Mimicking Human Age-Related Macular Degeneration

PURPOSE: Senescent Ccl2(-/-) mice are reported to develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are also found to be associated with AMD. The authors generated Ccl2(-/-)/Cx3cr1(-/-) mice to establish a more c...

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Detalhes bibliográficos
Main Authors: Tuo, Jingsheng, Bojanowski, Christine M., Zhou, Min, Shen, Defen, Ross, Robert J., Rosenberg, Kevin I., Cameron, D. Joshua, Yin, Chunyue, Kowalak, Jeffrey A., Zhuang, Zhengping, Zhang, Kang, Chan, Chi-Chao
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2048751/
https://ncbi.nlm.nih.gov/pubmed/17652758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.07-0051
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