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Ccl2/Cx3cr1-Deficient Mice: An Animal Model for Age-Related Macular Degeneration
BACKGROUND/AIMS: Senescent Ccl2(−/−) mice develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are associated with AMD. METHODS: We generated Ccl2(−/−)/Cx3cr1(−/−) [double-knockout (DKO)] mice and evaluated the eyes...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2409067/ https://ncbi.nlm.nih.gov/pubmed/18421225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000119862 |
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