Ccl2/Cx3cr1-Deficient Mice: An Animal Model for Age-Related Macular Degeneration

BACKGROUND/AIMS: Senescent Ccl2(−/−) mice develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are associated with AMD. METHODS: We generated Ccl2(−/−)/Cx3cr1(−/−) [double-knockout (DKO)] mice and evaluated the eyes...

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Detalhes bibliográficos
Main Authors: Chan, Chi-Chao, Ross, Robert J., Shen, Defen, Ding, Xiaoyan, Majumdar, Zigurts, Bojanowski, Christine M., Zhou, Min, Salem, Norman, Bonner, Robert, Tuo, Jingsheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409067/
https://ncbi.nlm.nih.gov/pubmed/18421225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000119862
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