Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes

AIMS: UGT1A1 and UGT2B7 are enzymes that commonly contribute to drug glucuronidation. Since genetic factors have been suggested to contribute to variability in activities and expression levels of these enzymes, a quantitative assessment of the influence of the major genotypes (UGT1A1*28 or UGT2B7*2)...

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Hlavní autoři: Peterkin, Vincent C, Bauman, Jonathan N, Goosen, Theunis C, Menning, Lee, Man, Michael Z, Paulauskis, Joseph D, Williams, J Andrew, Myrand, Scott P
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2007
Témata:
Drug Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2048551/
https://ncbi.nlm.nih.gov/pubmed/17555467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02923.x
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