An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication

One of the first steps in HIV gene expression is the recruitment of Tat protein to the transcription machinery after its binding to the RNA response element TAR. Starting from a pool of 3.2 × 10(6) individual chemical entities, we were able to select a hybrid peptoid/peptide oligomer of 9 residues (...

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Bibliografiske detaljer
Main Authors: Hamy, François, Felder, Eduard R., Heizmann, Gerhard, Lazdins, Janis, Aboul-ela, Fareed, Varani, Gabriele, Karn, Jonathan, Klimkait, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences of the USA 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC20476/
https://ncbi.nlm.nih.gov/pubmed/9108013
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