The Mx1 Gene Protects Mice against the Pandemic 1918 and Highly Lethal Human H5N1 Influenza Viruses

Mice carrying a wild-type Mx1 gene (Mx1(+/+)) differ from standard laboratory mice (Mx1(−/−)) in being highly resistant to infection with common laboratory strains of influenza A virus. We report that Mx1 also protects mice against the pandemic human 1918 influenza virus and a highly lethal human H5...

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Detalhes bibliográficos
Main Authors: Tumpey, Terrence M., Szretter, Kristy J., Van Hoeven, Neal, Katz, Jacqueline M., Kochs, Georg, Haller, Otto, García-Sastre, Adolfo, Staeheli, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045488/
https://ncbi.nlm.nih.gov/pubmed/17652381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01116-07
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