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Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene
The IFN-induced resistance factor Mx1 is a critical component of innate immunity against influenza A viruses (FLUAV) in mice. Animals carrying a wild-type Mx1 gene (Mx1(+/+)) differ from regular laboratory mice (Mx1(−/−)) in that they are highly resistant to infection with standard FLUAV strains. We...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1871866/ https://ncbi.nlm.nih.gov/pubmed/17426143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701849104 |
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