Replication-Competent Variants of Human Immunodeficiency Virus Type 2 Lacking the V3 Loop Exhibit Resistance to Chemokine Receptor Antagonists

Entry of human immunodeficiency virus type 1 (HIV-1) and HIV-2 requires interactions between the envelope glycoprotein (Env) on the virus and CD4 and a chemokine receptor, either CCR5 or CXCR4, on the cell surface. The V3 loop of the HIV gp120 glycoprotein plays a critical role in this process, dete...

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Detalhes bibliográficos
Main Authors: Lin, George, Bertolotti-Ciarlet, Andrea, Haggarty, Beth, Romano, Josephine, Nolan, Katrina M., Leslie, George J., Jordan, Andrea P.-O., Huang, Chih-chin, Kwong, Peter D., Doms, Robert W., Hoxie, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045409/
https://ncbi.nlm.nih.gov/pubmed/17609282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00385-07
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