Distinct Molecular Pathways to X4 Tropism for a V3-Truncated Human Immunodeficiency Virus Type 1 Lead to Differential Coreceptor Interactions and Sensitivity to a CXCR4 Antagonist

During the course of infection, transmitted HIV-1 isolates that initially use CCR5 can acquire the ability to use CXCR4, which is associated with an accelerated progression to AIDS. Although this coreceptor switch is often associated with mutations in the stem of the viral envelope (Env) V3 loop, do...

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Hlavní autoři: Del Prete, Gregory Q., Leslie, George J., Haggarty, Beth, Jordan, Andrea P. O., Romano, Josephine, Hoxie, James A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919036/
https://ncbi.nlm.nih.gov/pubmed/20573813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00333-10
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