Astrocyte Indoleamine 2,3-Dioxygenase Is Induced by the TLR3 Ligand Poly(I:C): Mechanism of Induction and Role in Antiviral Response

Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in the kynurenine pathway of tryptophan catabolism and has been implicated in neurotoxicity and suppression of the antiviral T-cell response in HIV encephalitis (HIVE). Here we show that the Toll-like receptor 3 (TLR3) ligand po...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Suh, Hyeon-Sook, Zhao, Meng-Liang, Rivieccio, Mark, Choi, Shinyeop, Connolly, Erin, Zhao, Yongmei, Takikawa, Osamu, Brosnan, Celia F., Lee, Sunhee C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2007
Gaiak:
Cellular Response to Infection
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045380/
https://ncbi.nlm.nih.gov/pubmed/17626075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00792-07
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