Development and Evaluation of a Line Probe Assay for Rapid Identification of pncA Mutations in Pyrazinamide-Resistant Mycobacterium tuberculosis Strains

Resistance of Mycobacterium tuberculosis to pyrazinamide (PZA) derives mainly from mutations in the pncA gene. We developed a reverse hybridization-based line probe assay with oligonucleotide probes designed to detect mutations in pncA. The detection of PZA resistance was evaluated in 258 clinical i...

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Detalhes bibliográficos
Main Authors: Sekiguchi, Jun-Ichiro, Nakamura, Tomohiko, Miyoshi-Akiyama, Tohru, Kirikae, Fumiko, Kobayashi, Intetsu, Augustynowicz-Kopeć, Ewa, Zwolska, Zofia, Morita, Koji, Suetake, Toshinori, Yoshida, Hiroshi, Kato, Seiya, Mori, Toru, Kirikae, Teruo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Mycobacteriology and Aerobic Actinomycetes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045301/
https://ncbi.nlm.nih.gov/pubmed/17596354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00352-07
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