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Pluripotency deficit in clones overcome by clone–clone aggregation: epigenetic complementation?

Abnormal gene expression patterns in somatic cell clones and their attrition in utero are commonly considered a consequence of errors in nuclear reprogramming. We observe that mouse clone blastocysts have less than half the normal cell number, and that higher cell number correlates with correct expr...

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Autori principali: Boiani, Michele, Eckardt, Sigrid, Leu, N.Adrian, Schöler, Hans R., McLaughlin, K.John
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC204490/
https://ncbi.nlm.nih.gov/pubmed/14517267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg507
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