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Force-dependent integrin–cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2

As cells encounter new regions of the substrate, they develop bonds with new matrix molecules for migration, matrix remodeling and force generation. How cells orchestrate the assembly of adhesion sites is only partially understood. Here we show that fibroblasts deficient in the SH2 domain containing...

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Bibliographic Details
Main Authors: von Wichert, Götz, Haimovich, Beatrice, Feng, Gen-Sheng, Sheetz, Michael P.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC204475/
https://ncbi.nlm.nih.gov/pubmed/14517241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg492
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