Identification and Characterization of UK-201844, a Novel Inhibitor That Interferes with Human Immunodeficiency Virus Type 1 gp160 Processing

More than 10(6) compounds were evaluated in a human immunodeficiency virus type 1 (HIV-1) high-throughput antiviral screen, resulting in the identification of a novel HIV-1 inhibitor (UK-201844). UK-201844 exhibited antiviral activity against HIV-1 NL4-3 in MT-2 and PM1 cells, with 50% effective con...

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Detalhes bibliográficos
Main Authors: Blair, Wade S., Cao, Joan, Jackson, Lynn, Jimenez, Judith, Peng, Qinghai, Wu, Hua, Isaacson, Jason, Butler, Scott L., Chu, Alex, Graham, Joanne, Malfait, Anne-Marie, Tortorella, Micky, Patick, Amy K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043256/
https://ncbi.nlm.nih.gov/pubmed/17646410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00643-07
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