In Vitro Antiviral Activity of the Novel, Tyrosyl-Based Human Immunodeficiency Virus (HIV) Type 1 Protease Inhibitor Brecanavir (GW640385) in Combination with Other Antiretrovirals and against a Panel of Protease Inhibitor-Resistant HIV

Brecanavir, a novel tyrosyl-based arylsulfonamide, high-affinity, human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI), has been evaluated for anti-HIV activity in several in vitro assays. Preclinical assessment of brecanavir indicated that this compound potently inhibited HIV-1 in ce...

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Autori principali: Hazen, Richard, Harvey, Robert, Ferris, Robert, Craig, Charles, Yates, Phillip, Griffin, Philip, Miller, John, Kaldor, Istvan, Ray, John, Samano, Vincente, Furfine, Eric, Spaltenstein, Andrew, Hale, Michael, Tung, Roger, St. Clair, Marty, Hanlon, Mary, Boone, Lawrence
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043237/
https://ncbi.nlm.nih.gov/pubmed/17620375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00401-07
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