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The development of hypocretin deficiency in ataxin-hypocretin transgenic rats
Narcolepsy is linked to a widespread loss of neurons containing the neuropeptide hypocretin (HCRT), also named orexin. A transgenic (TG) rat model has been developed to mimic the neuronal loss found in narcoleptic humans. In these rats, HCRT neurons gradually die as a result of the expression of a p...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2042962/ https://ncbi.nlm.nih.gov/pubmed/17618058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2007.05.029 |
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