The development of hypocretin deficiency in ataxin-hypocretin transgenic rats

Narcolepsy is linked to a widespread loss of neurons containing the neuropeptide hypocretin (HCRT), also named orexin. A transgenic (TG) rat model has been developed to mimic the neuronal loss found in narcoleptic humans. In these rats, HCRT neurons gradually die as a result of the expression of a p...

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Autori principali: Zhang, Shengwen, Lin, Ling, Kaur, Satvinder, Thankachan, Stephen, Blanco-Centurion, Carlos, Yanagisawa, Masashi, Mignot, Emmanuel, Shiromani, Priyattam J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042962/
https://ncbi.nlm.nih.gov/pubmed/17618058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2007.05.029
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