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Dimethyl sulphoxide relaxes rabbit detrusor muscle by decreasing the Ca(2+) sensitivity of the contractile apparatus

BACKGROUND AND PURPOSE: The intravesical administration of dimethyl sulphoxide (DMSO) is used to alleviate the symptoms of interstitial cystitis. We investigated the relaxant effect of DMSO and its underlying mechanism in the detrusor muscle. EXPERIMENTAL APPROACH: The effects of DMSO on contraction...

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Detalhes bibliográficos
Main Authors: Shiga, K-i, Hirano, K, Nishimura, J, Niiro, N, Naito, S, Kanaide, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042939/
https://ncbi.nlm.nih.gov/pubmed/17549043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707317
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