Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB(2)) selective ligand AM1241 and its resolved enantiomers

BACKGROUND AND PURPOSE: Racemic (R,S) AM1241 is a cannabinoid receptor 2 (CB(2))-selective aminoalkylindole with antinociceptive efficacy in animal pain models. The purpose of our studies was to provide a characterization of R,S-AM1241 and its resolved enantiomers in vitro and in vivo. EXPERIMENTAL...

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Detalhes bibliográficos
Main Authors: Bingham, B, Jones, P G, Uveges, A J, Kotnis, S, Lu, P, Smith, V A, Sun, S-C, Resnick, L, Chlenov, M, He, Y, Strassle, B W, Cummons, T A, Piesla, M J, Harrison, J E, Whiteside, G T, Kennedy, J D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042933/
https://ncbi.nlm.nih.gov/pubmed/17549048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707303
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