Pharmacokinetics of the individual enantiomers of vigabatrin in neonates with uncontrolled seizures

The antiepileptic drug vigabatrin (VGB) is a selective irreversible inhibitor of GABA-transaminase. It is administered as a racemic R(−), S(+) mixture, but the pharmacological activity of vigabatrin resides in the S(+) enantiomer and the R(−) enantiomer is inactive. The pharmacokinetic parameters of...

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Bibliographic Details
Main Authors: VAUZELLE-KERVROËDAN, F., REY, E., PONS, G., d'ATHIS, Ph., CHIRON, C., DULAC, O., DUMAS, C., OLIVE, G.
Format: Artigo
Language:Inglês
Published: 1996
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042707/
https://ncbi.nlm.nih.gov/pubmed/8971436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1996.00495.x
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