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Polyreactive anti-DNA monoclonal antibodies and a derived peptide as vectors for the intracytoplasmic and intranuclear translocation of macromolecules

Naturally occurring polyreactive anti-DNA mAbs derived from a nonimmunized (NZB × NZW)F(1) mouse with spontaneous lupus erythematosus penetrated and accumulated in the nuclei of a variety of cultured cells. These mAbs and their F(ab′)2 and Fab′ fragments, covalently coupled to fluorescein, peroxidas...

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Main Authors: Avrameas, Alexandre, Ternynck, Thérèse, Nato, Faridabano, Buttin, Gérard, Avrameas, Stratis
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC20424/
https://ncbi.nlm.nih.gov/pubmed/9576929
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