Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia

Activin A is a member of the transforming growth factor-β superfamily, which we have identified as having a role in inflammatory responses. We show that circulating levels of activin increase rapidly after LPS-induced challenge through activation of Toll-like receptor 4 and the key adaptor protein,...

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Bibliographic Details
Main Authors: Jones, Kristian L., Mansell, Ashley, Patella, Shane, Scott, Bernadette J., Hedger, Mark P., de Kretser, David M., Phillips, David J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042191/
https://ncbi.nlm.nih.gov/pubmed/17911255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705971104
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