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Disease-associated mutant α-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity
α-Actinin-4 is a widely expressed protein that employs an actin-binding site with two calponin homology domains to crosslink actin filaments (F-actin) in a Ca(2+)-sensitive manner in vitro. An inherited, late-onset form of kidney failure is caused by point mutations in the α-actinin-4 actin-binding...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2042165/ https://ncbi.nlm.nih.gov/pubmed/17901210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702451104 |
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