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Crystal structure of the actin-binding domain of α-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis
Mutations in α-actinin-4 have been linked to familial focal segmental glomerulosclerosis (FSGS), a common renal disorder in humans, and produce an apparent increase in the actin-binding affinity of α-actinin-4 in vitro. One of the mutations in particular, Lys255Glu, falls in the middle of the actin-...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2255586/ https://ncbi.nlm.nih.gov/pubmed/18164029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.11.084 |
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