Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets

Circulating human platelets lack nuclei, cannot synthesize mRNA, and are considered incapable of regulated protein synthesis. We found that thrombin-activated, but not resting, platelets synthesize Bcl-3, a member of the IκB-α family of regulatory proteins. The time- and concentration-dependent gene...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Weyrich, Andrew S., Dixon, Dan A., Pabla, Ravinder, Elstad, Mark R., McIntyre, Thomas M., Prescott, Stephen M., Zimmerman, Guy A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1998
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9576921/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.10.5556
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