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Demethylation of a specific hypersensitive site in the Th2 locus control region

A growing body of literature has examined and implicated DNA methylation as a critical epigenetic modification in T helper (Th) cell differentiation. The absence of DNA methyltransferases or methyl-binding proteins derepresses many cytokine loci, allowing their ectopic expression, while methylation...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kim, Sean T., Fields, Patrick E., Flavell, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040439/
https://ncbi.nlm.nih.gov/pubmed/17940027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708293104
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