Genetic, biochemical, and crystallographic characterization of Fhit–substrate complexes as the active signaling form of Fhit

Alterations in the FHIT gene at 3p14.2 occur as early and frequent events in the development of several common human cancers. The ability of human Fhit-negative cells to form tumors in nude mice is suppressed by stable reexpression of Fhit protein. Fhit protein is a diadenosine P(1),P(3)-triphosphat...

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Autores principales: Pace, Helen C., Garrison, Preston N., Robinson, Angela K., Barnes, Larry D., Draganescu, Alexandra, Rösler, Angelika, Blackburn, G. Michael, Siprashvili, Zurab, Croce, Carlo M., Huebner, Kay, Brenner, Charles
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1998
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC20403/
https://ncbi.nlm.nih.gov/pubmed/9576908
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