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Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators
A series of nonsteroidal ligands were synthesized as second-generation agonists for the androgen receptor (AR). These ligands were designed to eliminate metabolic sites identified in one of our first-generation AR agonists, which was inactive in vivo due to its rapid metabolism to inactive constitue...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040239/ https://ncbi.nlm.nih.gov/pubmed/14761201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm030336u |
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