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Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators

A series of nonsteroidal ligands were synthesized as second-generation agonists for the androgen receptor (AR). These ligands were designed to eliminate metabolic sites identified in one of our first-generation AR agonists, which was inactive in vivo due to its rapid metabolism to inactive constitue...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Marhefka, Craig A., Gao, Wenqing, Chung, Kiwon, Kim, Juhyun, He, Yali, Yin, Donghua, Bohl, Casey, Dalton, James T., Miller, Duane D.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2004
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040239/
https://ncbi.nlm.nih.gov/pubmed/14761201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm030336u
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