Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-dependent and p53-independent mechanisms.

BACKGROUND: The MDM2 oncogene is amplified or overexpressed in many human cancers and MDM2 levels are associated with poor prognosis. MDM2 not only serves as a negative regulator of p53 but also has p53-independent activities. This study investigates the functions of the MDM2 oncogene in colon cance...

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Main Authors: Wang, Hui, Nan, Li, Yu, Dong, Lindsey, J. Russell, Agrawal, Sudhir, Zhang, Ruiwen
Formato: Artigo
Idioma:Inglês
Publicado: 2002
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2039984/
https://ncbi.nlm.nih.gov/pubmed/12149568
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