Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIα subunit of protein kinase A after oral administration

Overexpression of the RIα subunit of cAMP-dependent protein kinase (PKA) has been demonstrated in various human cancers. PKA has been suggested as a potential target for cancer therapy. The goal of the present study was to evaluate an anti-PKA antisense oligonucleotide (mixed-backbone oligonucleotid...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wang, Hui, Cai, Qiuyin, Zeng, Xiaofei, Yu, Dong, Agrawal, Sudhir, Zhang, Ruiwen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24178/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10570186/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.24.13989
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