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Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIα subunit of protein kinase A after oral administration

Overexpression of the RIα subunit of cAMP-dependent protein kinase (PKA) has been demonstrated in various human cancers. PKA has been suggested as a potential target for cancer therapy. The goal of the present study was to evaluate an anti-PKA antisense oligonucleotide (mixed-backbone oligonucleotid...

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Autors principals: Wang, Hui, Cai, Qiuyin, Zeng, Xiaofei, Yu, Dong, Agrawal, Sudhir, Zhang, Ruiwen
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC24178/
https://ncbi.nlm.nih.gov/pubmed/10570186
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