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Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors
Werner syndrome (WS) is a severe recessive disorder characterized by premature aging, cancer predisposition and genomic instability. The gene mutated in WS encodes a bi-functional enzyme called WRN that acts as a RecQ-type DNA helicase and a 3′-5′ exonuclease, but its exact role in DNA metabolism is...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2034464/ https://ncbi.nlm.nih.gov/pubmed/17715146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm500 |
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