MRE11 complex links RECQ5 helicase to sites of DNA damage

RECQ5 DNA helicase suppresses homologous recombination (HR) possibly through disruption of RAD51 filaments. Here, we show that RECQ5 is constitutively associated with the MRE11–RAD50–NBS1 (MRN) complex, a primary sensor of DNA double-strand breaks (DSBs) that promotes DSB repair and regulates DNA da...

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Bibliografski detalji
Glavni autori: Zheng, Lu, Kanagaraj, Radhakrishnan, Mihaljevic, Boris, Schwendener, Sybille, Sartori, Alessandro A., Gerrits, Bertran, Shevelev, Igor, Janscak, Pavel
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2009
Teme:
Nucleic Acid Enzymes
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677886/
https://ncbi.nlm.nih.gov/pubmed/19270065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp147
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