MRE11 complex links RECQ5 helicase to sites of DNA damage

RECQ5 DNA helicase suppresses homologous recombination (HR) possibly through disruption of RAD51 filaments. Here, we show that RECQ5 is constitutively associated with the MRE11–RAD50–NBS1 (MRN) complex, a primary sensor of DNA double-strand breaks (DSBs) that promotes DSB repair and regulates DNA da...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zheng, Lu, Kanagaraj, Radhakrishnan, Mihaljevic, Boris, Schwendener, Sybille, Sartori, Alessandro A., Gerrits, Bertran, Shevelev, Igor, Janscak, Pavel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2009
Gaiak:
Nucleic Acid Enzymes
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677886/
https://ncbi.nlm.nih.gov/pubmed/19270065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp147
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