MRE11 complex links RECQ5 helicase to sites of DNA damage

RECQ5 DNA helicase suppresses homologous recombination (HR) possibly through disruption of RAD51 filaments. Here, we show that RECQ5 is constitutively associated with the MRE11–RAD50–NBS1 (MRN) complex, a primary sensor of DNA double-strand breaks (DSBs) that promotes DSB repair and regulates DNA da...

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Detalhes bibliográficos
Main Authors: Zheng, Lu, Kanagaraj, Radhakrishnan, Mihaljevic, Boris, Schwendener, Sybille, Sartori, Alessandro A., Gerrits, Bertran, Shevelev, Igor, Janscak, Pavel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677886/
https://ncbi.nlm.nih.gov/pubmed/19270065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp147
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