Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

Werner syndrome (WS) is a severe recessive disorder characterized by premature aging, cancer predisposition and genomic instability. The gene mutated in WS encodes a bi-functional enzyme called WRN that acts as a RecQ-type DNA helicase and a 3′-5′ exonuclease, but its exact role in DNA metabolism is...

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Bibliographic Details
Main Authors: Saydam, Nurten, Kanagaraj, Radhakrishnan, Dietschy, Tobias, Garcia, Patrick L., Peña-Diaz, Javier, Shevelev, Igor, Stagljar, Igor, Janscak, Pavel
Format: Artigo
Language:Inglês
Published: Oxford University Press 2007
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034464/
https://ncbi.nlm.nih.gov/pubmed/17715146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm500
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