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Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastases

BACKGROUND: C4-2 prostate cancer (CaP) cells grown in mouse tibiae cause a mixed osteoblastic/osteolytic response with increases in osteoclast numbers and bone resorption. Administration of osteoprotegerin (OPG) blocks these increases, indicating the critical role of RANKL in osteolysis in this mode...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Morrissey, Colm, Kostenuik, Paul L, Brown, Lisha G, Vessella, Robert L, Corey, Eva
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BioMed Central 2007
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034387/
https://ncbi.nlm.nih.gov/pubmed/17683568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-7-148
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