Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastases

BACKGROUND: C4-2 prostate cancer (CaP) cells grown in mouse tibiae cause a mixed osteoblastic/osteolytic response with increases in osteoclast numbers and bone resorption. Administration of osteoprotegerin (OPG) blocks these increases, indicating the critical role of RANKL in osteolysis in this mode...

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Autori principali: Morrissey, Colm, Kostenuik, Paul L, Brown, Lisha G, Vessella, Robert L, Corey, Eva
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034387/
https://ncbi.nlm.nih.gov/pubmed/17683568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-7-148
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