Differential susceptibility of S and M phase cyclin/CDK complexes to inhibitory tyrosine phosphorylation in yeast

BACKGROUND: Several checkpoint pathways employ Wee1-mediated inhibitory tyrosine phosphorylation of cyclin-dependent kinases (CDKs) to restrain cell-cycle progression. Whereas in vertebrates this strategy can delay both DNA replication and mitosis, in yeast cells only mitosis is delayed. This is par...

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Main Authors: Keaton, Mignon A., Bardes, Elaine S. G., Marquitz, Aron R., Freel, Christopher D., Zyla, Trevin R., Rudolph, Johannes, Lew, Daniel J.
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034293/
https://ncbi.nlm.nih.gov/pubmed/17614281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2007.05.075
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