A small-molecule therapeutic lead for Huntington's disease: Preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse

Huntington's disease (HD) is a progressive neurodegenerative disease caused by a glutamine expansion within huntingtin protein. The exact pathological mechanisms determining disease onset and progression remain unclear. However, aggregates of insoluble mutant huntingtin (mhtt), a hallmark of HD...

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Bibliographic Details
Main Authors: Chopra, Vanita, Fox, Jonathan H., Lieberman, Greg, Dorsey, Kathryn, Matson, Wayne, Waldmeier, Peter, Housman, David E., Kazantsev, Aleksey, Young, Anne B., Hersch, Steven
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034257/
https://ncbi.nlm.nih.gov/pubmed/17925440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707842104
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