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Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations
Cancer is a disease of aging. The accumulation of mutations in individual cells over a lifetime is thought to be the reason. In this work, we explored an additional hypothesis: could p53 function decline with age, which would contribute to an enhanced mutation frequency and tumorigenesis in the agin...
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| Main Authors: | , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
National Academy of Sciences
2007
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2034252/ https://ncbi.nlm.nih.gov/pubmed/17921246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708043104 |
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