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Kinetic evidence for a ligand-binding-induced conformational transition in the T cell receptor

Thermodynamics and kinetics of the interaction between T cell receptor specific for cytomegalovirus peptide (TCR(CMV)) and its specific ligand, pp65–HLA-A*0201 complex, were studied by surface plasmon resonance and stopped-flow methods. In the latter measurements, fluorescence resonance energy trans...

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Detalhes bibliográficos
Main Authors: Gakamsky, Dmitry M., Lewitzki, Erwin, Grell, Ernst, Saulquin, Xavier, Malissen, Bernard, Montero-Julian, Felix, Bonneville, Marc, Pecht, Israel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034217/
https://ncbi.nlm.nih.gov/pubmed/17921250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707061104
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