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Hyperthermia, thermotolerance and topoisomerase II inhibitors.

The cytoxicity of both intercalating (m-AMSA) and non-intercalating (VP16, VM26) topoisomerase II-targeting drugs is thought to occur via trapping DNA topoisomerase II on DNA in the form of cleavable complexes. First, analysis of cleavable complexes (detected as DNA double-strand breaks) by pulsed-f...

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Autor principal: Kampinga, H. H.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1995
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033976/
https://ncbi.nlm.nih.gov/pubmed/7640214
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