Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines.

Topoisomerase II is a key target for many anti-cancer drugs used to treat breast cancer. In human cells there are two closely related, but differentially expressed, topoisomerase II isoforms, designated topoisomerase II alpha and beta. Here, we report the production of a new polyclonal antibody rais...

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Main Authors: Houlbrook, S., Addison, C. M., Davies, S. L., Carmichael, J., Stratford, I. J., Harris, A. L., Hickson, I. D.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1995
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034103/
https://ncbi.nlm.nih.gov/pubmed/8519659
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