Molecular genetic evidence for unifocal origin of advanced epithelial ovarian cancer and for minor clonal divergence.

Detection of loss of heterozygosity (LOH) and DNA flow cytometry (FCM) were used to trace the origin of bilateral ovarian cancer from 16 patients. From each tumour the DNA index (DI) and LOH patterns for chromosomes 1, 3, 6, 11, 17, 18, 22 and X were determined with 36 microsatellite markers. Formal...

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Bibliografische gegevens
Hoofdauteurs: Abeln, E. C., Kuipers-Dijkshoorn, N. J., Berns, E. M., Henzen-Logmans, S. C., Fleuren, G. J., Cornelisse, C. J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 1995
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033953/
https://ncbi.nlm.nih.gov/pubmed/7577492
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