Molecular genetic evidence for unifocal origin of advanced epithelial ovarian cancer and for minor clonal divergence.

Detection of loss of heterozygosity (LOH) and DNA flow cytometry (FCM) were used to trace the origin of bilateral ovarian cancer from 16 patients. From each tumour the DNA index (DI) and LOH patterns for chromosomes 1, 3, 6, 11, 17, 18, 22 and X were determined with 36 microsatellite markers. Formal...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Abeln, E. C., Kuipers-Dijkshoorn, N. J., Berns, E. M., Henzen-Logmans, S. C., Fleuren, G. J., Cornelisse, C. J.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 1995
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033953/
https://ncbi.nlm.nih.gov/pubmed/7577492
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