Molecular design of hybrid tumour necrosis factor alpha with polyethylene glycol increases its anti-tumour potency.

This study was conducted to increase the anti-tumour potency and reduce the toxic side-effects of tumour necrosis factor alpha (TNF-alpha). Natural human TNF-alpha was chemically conjugated with monomethoxy polyethylene glycol (PEG) using succinimidyl coupling of lysine amino groups of TNF-alpha. Th...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Tsutsumi, Y., Kihira, T., Tsunoda, S., Kanamori, T., Nakagawa, S., Mayumi, T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 1995
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033790/
https://ncbi.nlm.nih.gov/pubmed/7734321
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