Chemical Modification of Natural Human Tumor Necrosis Factor‐α with Polyethylene Glycol Increases Its Anti‐tumor Potency

Natural human tumor necrosis factor‐α (TNF‐α) was chemically modified with an active ester of monomethoxy polyethylene glycol (PEG). The molecular weight of PEG‐modified TNF‐a depended on the reaction time as well as the initial molar ratio of PEG to TNF‐α. The specific activity of modified TNF‐α wa...

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Bibliographic Details
Published in:Jpn J Cancer Res
Main Authors: Tsutsumi, Yasuo, Kihira, Tetsunari, Yamamoto, Susumu, Kubo, Kazuyoshi, Nakagawa, Shinsaku, Miyake, Masaharu, Horisawa, Yoshifumi, Kanamori, Toshinori, Ikegami, Hakuo, Mayumi, Tadanori
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 1994
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919344/
https://ncbi.nlm.nih.gov/pubmed/8106293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1994.tb02879.x
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