In vivo Anti‐tumor Efficacy of Polyethylene Glycol‐modified Tumor Necrosis Factor‐α against Tumor Necrosis Factor‐resistant Tumors

We previously reported that the optimally PEGylated tumor necrosis factor‐α (MPEG‐TNF‐α), in which 56% of the TNF‐α‐lysine amino groups were coupled with polyethylene glycol (PEG), had about 100‐fold greater anti‐tumor effect than native TNF‐α. Here, we assessed the usefulness of MPEG‐TNF‐α as a sys...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Tsutsumi, Yasuo, Tsunoda, Shinichi, Kaneda, Yoshihisa, Kamada, Haruhiko, Kihira, Tetsunari, Nakagawa, Shinsaku, Yamamoto, Yoko, Horisawa, Yoshifumi, Mayumi, Tadanori
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1996
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920990/
https://ncbi.nlm.nih.gov/pubmed/8957067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1996.tb03113.x
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