Crystal structure of NaeI—an evolutionary bridge between DNA endonuclease and topoisomerase

NaeI is transformed from DNA endonuclease to DNA topoisomerase and recombinase by a single amino acid substitution. The crystal structure of NaeI was solved at 2.3 Å resolution and shows that NaeI is a dimeric molecule with two domains per monomer. Each domain contains one potential DNA recognition...

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Bibliographic Details
Main Authors: Huai, Qing, Colandene, James D., Chen, Yongquan, Luo, Feng, Zhao, Yingdong, Topal, Michael D., Ke, Hengming
Format: Artigo
Language:Inglês
Published: Oxford University Press 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC203366/
https://ncbi.nlm.nih.gov/pubmed/10856254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.12.3110
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