Phosphatidylinositol 3,4,5-trisphosphate regulates Ca(2+) entry via Btk in platelets and megakaryocytes without increasing phospholipase C activity

The role of phosphatidylinositol 3,4,5-trisphosphate (PI3,4,5P(3)) and Btk in signalling by the collagen receptor glycoprotein VI was investigated. PI3,4,5P(3) was increased in platelets from mice deficient in the SH2 domain-containing inositol 5-phosphatase (SHIP), in response to collagen related p...

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Detalhes bibliográficos
Main Authors: Pasquet, Jean-Max, Quek, Lynn, Stevens, Christiaan, Bobe, Régis, Huber, Michael, Duronio, Vincent, Krystal, Gerald, Watson, Steve P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC203356/
https://ncbi.nlm.nih.gov/pubmed/10856225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.12.2793
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