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Galactosylated streptavidin for improved clearance of biotinylated intact and F(ab')2 fragments of an anti-tumour antibody.

Persistence of high levels of radiolabelled antibody in the circulation is a major limitation of radioimmunotherapy. Biotinylation of the radiolabelled anti-tumour antibody followed by administration of streptavidin is known to give much improved tumour to blood ratios as the radioantibody is comple...

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Autori principali: Marshall, D., Pedley, R. B., Melton, R. G., Boden, J. A., Boden, R., Begent, R. H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1995
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033472/
https://ncbi.nlm.nih.gov/pubmed/7529526
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